ReviewEarly vascular aging and the role of central blood pressureKotsis, Vasiliosa,d; Stabouli, Stellaa,b; Karafillis, Ioannisa; Nilsson, Peterc,dAuthor Information aHypertension Center, 3rd Department of Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki bPediatric Intensive Care Unit, Hippokration Hospital, Thessaloniki, Greece cDepartment of Clinical Sciences, University Hospital, Lund University, Malmo, Sweden dDiabetes and Hypertension Working Group of the European Society of Hypertension Correspondence to Professor Vasilios Kotsis, MD, PhD, FESH, Head Hypertension-ABPM, Center Papageorgiou Hospital, 3 Filippoupoleos, Thessaloniki 55132, GreeceTel: +30 6974748860; fax: +30 2310452429; e-mail: email@example.com Abbreviations: EVA, early vascular aging; PWV, pulse wave velocity Received 7 January, 2011 Revised 16 June, 2011 Accepted 27 June, 2011 Journal of Hypertension: October 2011 - Volume 29 - Issue 10 - p 1847-1853 doi: 10.1097/HJH.0b013e32834a4d9f Buy Metrics Abstract Vascular aging is described as a gradual process involving biochemical, enzymatic, and cellular changes of the vasculature and modification of the signals that modulate them. On the basis of this conception a new pathophysiological model for deeper understanding of cardiovascular risk and its treatment was introduced. The idea of early vascular aging, that is the acceleration of vascular aging seems to be a promising tool for clinical guidance in individuals at increased cardiovascular risk or a strong family history of early cardiovascular manifestations. Increased arterial stiffness, dilation of central elastic arteries, impaired endothelial function and vasodilatation are dominant aspects of this premature process. © 2011 Lippincott Williams & Wilkins, Inc.