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Aortic stiffness is reduced beyond blood pressure lowering by short-term and long-term antihypertensive treatment: a meta-analysis of individual data in 294 patients

Ong, Kim-Thanha,b,c; Delerme, Samueld; Pannier, Brunob,e; Safar, Michel Ec,f; Benetos, Athanaseg; Laurent, Stéphanea,b,c; Boutouyrie, Pierrea,b,con behalf of the investigators

doi: 10.1097/HJH.0b013e328346a583
Reviews and meta-analyses

Background Arterial stiffness is an independent predictor of cardiovascular events and mortality in hypertensive patients. The influence of different antihypertensive drug classes on improving arterial stiffness beyond blood pressure reduction is not widely available. We aimed to determine whether the artery stiffness can be improved because of antihypertensive treatments independently of blood pressure lowering.

Methods We conducted a meta-analysis of individual data from 15 randomized, controlled, double-blind, parallel group trials performed in our laboratory between 1987 and 1994. The primary endpoint was the changes of carotid–femoral pulse wave velocity (PWV) after treatment in 294 patients with mild-to-moderate essential hypertension untreated. Treatments tested were placebo (n = 88), angiotensin-converting enzyme inhibitors (ACEIs) (n = 75), calcium antagonists (n = 75), beta-blocker (n = 30), and diuretic (n = 26).

Results In the short-term and long-term trials, PWV decreased significantly by −0.75 and −1.3 m/s in the active treatment group compared with by +0.17 and −0.44 m/s in the placebo group, respectively. Active treatment was independently related to the changes in PWV and explained 5 and 4% of the variance in the short-term and long-term trials, respectively. In the short-term trials, ACEIs were more effective than calcium antagonists and placebo on improving arterial stiffness. In the long-term trials, ACEI, calcium antagonists, beta-blocker, and diuretic reduced significantly PWV compared to placebo.

Conclusion Our study shows that antihypertensive treatments improve the arterial stiffness beyond their effect on blood pressure.

aAssistance Publique - Hôpitaux de Paris, Hôpital Européen Georges Pompidou, France

bINSERM U970, France

cUniversité Paris - Descartes, France

dAssistance Publique - Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris, France

eCentre Hospitalier M.H. Manhes, Fleury Mérogis, France

fAssistance Publique - Hôpitaux de Paris, Hôtel-Dieu, Centre de Diagnostic et de Thérapeutique, Paris, France

gCentre Hospitalier Universitaire de Nancy, INSERM U691, Université de Nancy, Nancy, France

*A complete list of authors is included in Acknowledgement section.

Received 12 October, 2010

Revised 10 March, 2011

Accepted 10 March, 2011

Correspondence to Professor Pierre Boutouyrie, MD, PhD, Department of Pharmacology, INSERM U970, Hôpital Européen Georges Pompidou, Assistance Publique – Hôpitaux de Paris, Université Paris Descartes, 20, rue Leblanc, 75015 Paris, France E-mail:

© 2011 Lippincott Williams & Wilkins, Inc.