Original papers: EpidemiologyMonosodium glutamate is related to a higher increase in blood pressure over 5 years: findings from the Jiangsu Nutrition Study of Chinese adultsShi, Zumina,b,c; Yuan, Baojuna; Taylor, Anne Wb,c; Dai, Yuea; Pan, Xiaoquna; Gill, Tiffany Kc; Wittert, Gary Ac Author Information aDepartment of Nutrition and Foodborne Disease Prevention, Jiangsu Provincial Centre for Disease Control and Prevention, Nanjing, China bPopulation Research and Outcome Studies Unit, Department of Health, Australia cDiscipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia Received 14 October, 2010 Revised 10 January, 2011 Accepted 20 January, 2011 Correspondence to Dr Zumin Shi, Department of Nutrition and Foodborne Disease Prevention, Jiangsu Provincial Centre for Disease Control and Prevention, 172 Jiangsu Road, Nanjing 210009, China Tel: +61 8 8313 1188; fax: +61 8 8313 1228; e-mail: [email protected] Journal of Hypertension: May 2011 - Volume 29 - Issue 5 - p 846-853 doi: 10.1097/HJH.0b013e328344da8e Buy Metrics Abstract Objective One large cross-sectional study across four countries suggests that glutamate intake may be inversely associated with blood pressure (BP). The aim of this analysis was to investigate a possible association between monosodium glutamate (MSG) intake and change in blood pressure over 5 years. Methods Data from 1227 Chinese men and women who participated in the Jiangsu Nutrition Study (JIN) were analyzed. In this study, MSG intake and blood pressure were quantitatively assessed in 2002, and followed-up in 2007. Results MSG intake was associated with a significant increase in SBP and DBP. A strong sex interaction was observed in relation to SBP change. Women with high MSG intake were more likely to have increased SBP and DBP. Total glutamate intake was also positively associated with an increase in SBP. In those chronically taking antihypertensive medications, there was a strong association between MSG intake and an increase in DBP. Conclusion MSG intake may have independent BP-increasing effects, especially among women and those taking hypertension medications at baseline and follow-up. © 2011 Lippincott Williams & Wilkins, Inc.