Original Papers: Blood vesselsComparison between carotid-femoral and brachial-ankle pulse wave velocity as measures of arterial stiffnessTanaka, Hirofumia; Munakata, Masanorib; Kawano, Yuheic; Ohishi, Mitsurud; Shoji, Tetsuoe; Sugawara, Juna; Tomiyama, Hirofumif; Yamashina, Akiraf; Yasuda, Hisayoc; Sawayama, Toshitamig; Ozawa, ToshiohAuthor Information aUniversity of Texas at Austin, Austin, Texas, USA bTohoku Rosai Hospital, Japan cNational Cardiovascular Center, Japan dOsaka University, Japan eOsaka City University, Japan fTokyo Medical University, Japan gSawayama Clinic, Japan hTokyo Metropolitan Geriatric Center, Japan Received 11 December, 2008 Revised 12 April, 2009 Accepted 21 May, 2009 Correspondence to Hirofumi Tanaka, PhD, Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX 78712, USA Tel: +1 512 232 4801; fax: +1 512 471 0946; e-mail: [email protected] Journal of Hypertension: October 2009 - Volume 27 - Issue 10 - p 2022-2027 doi: 10.1097/HJH.0b013e32832e94e7 Buy Metrics Abstract Background Arterial stiffness is an important risk factor for cardiovascular disease. Carotid-femoral pulse wave velocity (cfPWV) is the most recognized and established index of arterial stiffness. An emerging automatic measure of PWV primarily used in the Asian countries is brachial-ankle PWV (baPWV). Method To systematically compare these two methodologies, we conducted a multicenter study involving a total of 2287 patients. Results There was a significant positive relation between baPWV and cfPWV (r = 0.73). Average baPWV was approximately 20% higher than cfPWV. Both cfPWV and baPWV were significantly and positively associated with age (r = 0.56 and 0.64), systolic blood pressure (r = 0.49 and 0.61), and the Framingham risk score (r = 0.48 and 0.63). The areas under the receiver operating curves (ROCs) of PWV to predict the presence of both stroke and coronary artery disease were comparable between cfPWV and baPWV. Conclusion Collectively, these results indicate that cfPWV and baPWV are indices of arterial stiffness that exhibit similar extent of associations with cardiovascular disease risk factors and clinical events. © 2009 Lippincott Williams & Wilkins, Inc.