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Comparison between carotid-femoral and brachial-ankle pulse wave velocity as measures of arterial stiffness

Tanaka, Hirofumia; Munakata, Masanorib; Kawano, Yuheic; Ohishi, Mitsurud; Shoji, Tetsuoe; Sugawara, Juna; Tomiyama, Hirofumif; Yamashina, Akiraf; Yasuda, Hisayoc; Sawayama, Toshitamig; Ozawa, Toshioh

doi: 10.1097/HJH.0b013e32832e94e7
Original Papers: Blood vessels

Background Arterial stiffness is an important risk factor for cardiovascular disease. Carotid-femoral pulse wave velocity (cfPWV) is the most recognized and established index of arterial stiffness. An emerging automatic measure of PWV primarily used in the Asian countries is brachial-ankle PWV (baPWV).

Method To systematically compare these two methodologies, we conducted a multicenter study involving a total of 2287 patients.

Results There was a significant positive relation between baPWV and cfPWV (r = 0.73). Average baPWV was approximately 20% higher than cfPWV. Both cfPWV and baPWV were significantly and positively associated with age (r = 0.56 and 0.64), systolic blood pressure (r = 0.49 and 0.61), and the Framingham risk score (r = 0.48 and 0.63). The areas under the receiver operating curves (ROCs) of PWV to predict the presence of both stroke and coronary artery disease were comparable between cfPWV and baPWV.

Conclusion Collectively, these results indicate that cfPWV and baPWV are indices of arterial stiffness that exhibit similar extent of associations with cardiovascular disease risk factors and clinical events.

aUniversity of Texas at Austin, Austin, Texas, USA

bTohoku Rosai Hospital, Japan

cNational Cardiovascular Center, Japan

dOsaka University, Japan

eOsaka City University, Japan

fTokyo Medical University, Japan

gSawayama Clinic, Japan

hTokyo Metropolitan Geriatric Center, Japan

Received 11 December, 2008

Revised 12 April, 2009

Accepted 21 May, 2009

Correspondence to Hirofumi Tanaka, PhD, Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX 78712, USA Tel: +1 512 232 4801; fax: +1 512 471 0946; e-mail:

© 2009 Lippincott Williams & Wilkins, Inc.