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Cancer and hypertension: a potential for crosstalk?

Hamet, Pavel1,2

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Epidemiological evidence, particularly from prospective studies, points to the possibility that there is a weak but significantly increased risk of cancer in hypertension. Many classes of drugs have been accused of increasing the risk of cancer yet these studies were case–controlled and did not withstand prospective randomized evaluation. As our understanding of cellular biology and our capacity to dissect genetic components of complex diseases progress, we realize that many pathophysiological pathways are actually quite similar in distinct disorders such as cancer and hypertension. A question can therefore be asked: are the increased risks of cancer and hypertension not related to fundamentally shared pathways, since both disorders reflect proliferative abnormalities? We propose a search for such shared pathways.

1Centre de Recherche–CHUM, Montreal, Quebec, Canada.

2Requests for reprints to Pavel Hamet, Centre de Recherche–CHUM, Pavillon Hôtel-Dieu, Laboratory of Molecular Pathophysiology, 3850 St Urbain St., Montréal, Québec H2W 1T8, Canada.

Sponsorship: This work was supported in part by a grant from the Medical Research Council of Canada (MT-10803).

© Lippincott-Raven Publishers.