Original articlePrediction of mortality by ambulatory blood pressure monitoring versus screening blood pressure measurements a pilot study in OhasamaOhkubo, Takayoshi1,5; Imai, Yutaka2; Tsuji, Ichiro1; Nagai, Kenichi4; Watanabe, Noriko2; Minami, Naoyoshi2; Itoh, Osamu2; Bando, Takehiko1; Sakuma, Mariko2; Fukao, Akira1; Satoh, Hiroshi3; Hisamichi, Shigeru1; Abe, Keishi2 Author Information 1Department of Public Health, Tohoku University School of Medicine, Sendai, Japan 2Department of Medicine, Tohoku University School of Medicine, Sendai, Japan 3Environmental Health Science, Tohoku University School of Medicine, Sendai, Japan 4Department of Medicine, Ohasama Hospital, Iwate, Japan. 5Requests for reprints to Dr Takayoshi Ohkubo, Department of Public Health, Tohoku University School of Medicine, Sendai, 980-77, Japan. Sponsorship: This work was supported by research grants from the Miyagi Prefectural Kidney Association, the Takeda Medical Research Foundation, the National Center for Cardiovascular Disease (grants 4C-3 and 5C-2), the Ministry of Health and Welfare (for Evaluation of the Effect of Drug Treatment on Hypertension and Other Chronic Disease Conditions in the Elderly, Kosei-Kagaku Kenkyuhi, 1996, and Rojin Hoken Jigyo Suishin Hojokin, 1996), and the Ministry of Education, Science and Culture of Japan (grant 07670420). Received 15 April 1996 Revised 22 January 1997 Accepted 23 January 1997 Journal of Hypertension: April 1997 - Volume 15 - Issue 4 - p 357-364 Buy Abstract Objective To compare the prediction of mortality by ambulatory blood pressure monitoring and screening blood pressure measurements in a general population. Design A prospective cohort study. Patients and methods We obtained blood pressure data for 1542 subjects (565 men and 977 women) aged ≥ 40 years who were followed up for up to 8.1 years (mean 5.1 years). Subjects were subdivided into five groups according to their ambulatory and screening blood pressure levels. The prognostic significance of blood pressure for mortality was examined by the Cox proportional hazards regression model. Results The association between blood pressure level and mortality was more distinctive for the ambulatory blood pressure than it was for the screening blood pressure. The risk of cardiovascular mortality increased significantly for the highest quintiles of 24 h ambulatory blood pressure, whereas there was no significant association between the screening blood pressure and the cardiovascular mortality. When both 24 h and screening blood pressure values were included in the Cox model, only the systolic ambulatory blood pressure was related significantly to the increased risk of cardiovascular mortality. Conclusions The ambulatory blood pressure had a stronger predictive power for mortality than did the screening blood pressure. This appears to have been the first study of the prognostic significance of ambulatory blood pressure monitoring versus screening blood pressure measurements in a general population. © Lippincott-Raven Publishers.