ReviewEpidemiology of hypertension and insulin resistance syndromeHaffner, Steven M.1 Author Information 1Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA. Requests for reprints to Dr Steven M. Haffner, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284-7873, USA. Journal of Hypertension: Volume 15 - Issue 1 - p S25-S30 Buy Abstract Insulin resistance syndrome Insulin resistance syndrome (syndrome X) indicates that insulin resistance is associated with and may be the cause of several metabolic conditions including hypertension, dyslipidemia, non-insulin dependent diabetes mellitus (NIDDM). Hypertension Although the association between insulin resistance and hypertension remains somewhat controversial, hypertensive subjects are clearly at increased risk of developing NIDDM. Insulin concentrations are a relatively weak predictor of the development of hypertension. It is possible that the relation between insulin, blood pressure and atherosclerosis may be weaker in blacks. However, antihypertensive agents that worsen insulin resistance may further increase the risk of NIDDM already present in subjects with hypertension. © Lippincott-Raven Publishers.