ORIGINAL ARTICLE: PDF OnlyTrazzi Silvia; Santucciu, Cinzia; Mancia, GiuseppeJournal of Hypertension: 1993 - p S21 Buy Abstract Objective: To evaluate the effects of antihypertensvie therapy with lacidipine on the increase in radial artery compliance observed in mild essential hypertensive patients methods: The stuudy was performed in eight mild to moderate essential hypertensive patients in whom clinic blood pressure, radial artery diameter and radial artery compliance were evaluated before and after 3 months administration of lacidipine, at a single daily dose of 4 mag. radial artery diameter and compliance were evaluabted by means of a high precision eacho-tracking deviceable to assess arterial compliance over the blood pressure oscillations that characterize the cardiac cycle Results: Lacidipine treatment caused a significant reduction in clinic systolic and diastolic blood pressure. while her heart rate was not modified by the drug. radial artery diameter and compliance were both reduced by lacidipine over the entire systolodiastolic blood pressure range. Conclusion: Chronic administration of lacidipine seems to reverse the increase in compliance treatment can reverse an increase in the smooth muscle component in the arterial wall induced by hypertension Copyright © 1993 Wolters Kluwer Health, Inc. All rights reserved.