ORIGINAL ARTICLE: PDF OnlyRodicio José L.; Morales, Jose M.; Ruilope, Luis M.Journal of Hypertension: 1993 - p S27 Buy Abstract Aim: To review cyclosporin nephrotoxicity and its prevention by calcium antagonists Method: Review of published and unpublished studies. Results: Cyclosporin A newphrotoxicity is the most important side effect of this potent immunosuppressive drug. several mechanism have been implicated in the production of this adverse effect by elevated endothelin release is perhaps the most frequently cited cause. Calcium antagonists have hdemonstrated a beneficial effect in preventing cyclosporin A nephrotoxicity in renal cadaveric transplants, during both short-and long-term follow-up. Lacidipine, a lipopholic dihydropyridine calcium antagonist, prevents the reductions in the glomerular filtration rate and renal plasma flow that are often seen after cyclosporin A administration. This effect is not related to endothelin suppression. Conclusions: Calcium Antagonists can provide renal protection in patients who undergo renal cadaveric transplantation and are treated with cyclosporin. Copyright © 1993 Wolters Kluwer Health, Inc. All rights reserved.