Effects of calcium antagonists on pressor mechanism: A number of differences have been reported in the variable extent to which calcium antagonists membrance-binding characteristics and a prolonged duration of action apeear to be requirements for a calcium antagonist to affect mechanisms such as vasodlation, endogenous vasoconstrictor responses, hormone release and natriutretic activity.
Reduction in peripheral vascular resistance: A reduction in peripheral vascular resistance is fundamental to the antihypertensive effect not only of calcium ceptor antagonists. However, only the calcium antagonists interfere directly with the pressor responses mediated by both the adrenergic nervous system and the renin-angiotensin system.
mechanism of lacidipine effects: Preliminary result With the new dihydropyridine calcium antagonist lacidipine indicate that it not only has vasodilator activity but that it also interferes with both adrenergic and non-adrenergic endogenous vasoconstrictor mechanism. This may provide additional potentiallybeneficial cardiovascular effects, particularly in relation to left ventricular hypertrophyand dysfunction
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