Article: PDF OnlyThe cardiovascular effects of alpha-receptor blocking agentsLeren, PaulAuthor Information International Cardiological Institute for Therapeutic Research (ICIT), University of Oslo, The Research Park, Oslo, Norway. Requests for reprints to: Dr Paul Leren, Professor of Medicine, øvrevollveien 8 B, N-1342 Jar, Norway. Journal of Hypertension: Volume 10 - Issue - p S11-S16 Buy Abstract Objective To characterize selective α1-aadrenergic blockers as antihypertensive agents, particularly doxazosin. Characteristics of α-blockers These agents lower elevated blood pressure by reducing peripheral arterial resistance without increasing the heart rate or reducing cardiac output. They also reduce left ventricular hypertrophy; improve an atherogenic lipid profile; reduce the risk of thrombotic complications; reduce the formation of fatty streaks, the precursor of advanced athersclerosis; have no adverse metabolic effects in diabetic hypertensives; have a comparable side-effect profile to that of other antihypertensive drugs; and are cost-effective. Conclusions In addition to reducing high blood pressure, the α-blockers reduce a number of other cardiovascular risk factors. In attempts to solve the hypertension-coronary dilemma, these additional effects may prove to be of crucial importance. © Lippincott-Raven Publishers.