Original Papers: PDF OnlyEvidence for an intrinsic angiotensin system in the canine pancreasChappell, Mark C.; Millsted, Amy; Diz, Debra I.; Brosnihan, K Bridget; Ferrario, Carlos M.Author Information From the Department of Brain and Vascular Research, Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA. Journal of Hypertension: August 1991 - Volume 9 - Issue 8 - p 751-759 Buy Abstract Increasing evidence suggests an association between hypertension and abnormalities of glucose metabolism. Since components of the renin-angiotensin system exist in a variety of tissues consistent with paracrine actions of the peptide, we sought to determine whether the pancreas contains a local angiotensin system. We report the presence of angiotensinogen messenger (m) RNA, angiotensinogen protein, angiotensin II and high-affinity binding sites for angiotensin II in the canine pancreas. These novel findings establish a foundation for future studies to evaluate whether angiotensin acts as a paracrine regulator of endocrine and/or exocrine functions of the pancreas. © Lippincott-Raven Publishers.