Original papers: PDF OnlyAdrenalectomy causes a delayed increase of inactive plasma renin in ratsNielsen, Arne H.; Johannessen, Arne; Poulsen, Knud Author Information From the Institute for Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg C, Denmark Journal of Hypertension 9(3):p 239-240, March 1991. Buy Abstract Using a new assay for inactive renin in rat plasma, inactive renin was unchanged 24 h after bilateral adrenalectomy but increased about threefold, from 0.43 Coldblatt units (ClO/l (range 0.27-0.62 GU/I; n=14) to 1.24 GU/I (0.74-1.94 GU/I; n=14) after 48 h. The increase was abolished by substitution with the mineralocorticoid deoxycorticosterone acetate. The results are in accordance with the high plasma concentration of inactive renin, previously reported in humans with adrenal insufficiency, and do not support activation of inactive renin in the circulation. © Lippincott-Raven Publishers.
