Platelet sodium-proton exchange is increased in essential hypertension : Journal of Hypertension

Journal Logo

Rapid communication: PDF Only

Platelet sodium-proton exchange is increased in essential hypertension

Schmouder, Robert L.; Weder, Alan B.

Author Information
Journal of Hypertension 7(4):p 325-330, April 1989.


Transmembrane sodium-hydrogen (Na±-H± ) exchange was measured indirectly in human platelets as the amiloride-sensitive change in volume during incubation in isosmotic sodium propionate. After first establishing the reproducibility of the assay, we measured propionate-activated volume increases in platelets from 24 male essential hypertensive patients and 20 male normotensives. For the entire group, platelet Na±-H± exchange was significantly (P < 0.006) higher in hypertensives compared with normotensives. Unlike red blood cell (RDC) cation transport markers of hypertension, platelet Na±-H± exchange was elevated in both black and white hypertensives. Na±-H± exchange was significantly positively correlated with diastolic blood pressure and did not correlate significantly with age, body weight or body mass index. In addition, platelet Na±-H± exchange did not correlate significantly with red blood cell lithium-sodium countertransport activity. Platelet Na±-H± exchange deserves further study as a marker for pathophysiological abnormalities in human hypertension.

© Lippincott-Raven Publishers.

You can read the full text of this article if you:

Access through Ovid