Malignant pheochromocytoma: diagnosis and treatment in fifteen cases : Journal of Hypertension

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Malignant pheochromocytoma

diagnosis and treatment in fifteen cases

Guo, Ji-zhen*; Gong, Lang-sheng*; Chen, Shao-xing*; Luo, Bang-yao; Xu, Man-ying

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Journal of Hypertension 7(4):p 261-266, April 1989.


This study reviews the diagnosis and treatment of 15 patients with malignant pheochromocytoma (MP) between 1958 and 1986 in Shanghai Rui-jin Hospital. The main clinical features consisted of sustained elevation of arterial blood pressure, obviously increased catecholamine secretion and a sustained positive phentolamine test. Out of 15 patients only seven survived, two of whom suffered from paraplegia due to metastatic cordai compression. Compared with some earlier results, the prognosis was unsatisfactory. There were several factors which may have been responsible: (1) late diagnosis; (2) incomplete operation, and (3) no regular post-operative assessment of urinary biochemical changes. Because MP is a tumour with a low degree of malignancy, noting the above three factors and using 131I-MIBG to obtain accurate diagnosis and effective treatment enables a better prognosis of this disease.

© Lippincott-Raven Publishers.

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