Rapid communication: PDF OnlyChanged cyclic guanosine monophosphate atrial natriuretic factor relationship in hypertensive manBruun, Niels Eske*; Nielsen, Meta Damkjaer*; Skostt, Peter*‡; Giese, JoSrn*; Leth, Arne‡; Schütten, Hans Josrgen**; Rasmussen, Sten* Author Information *From the Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, Copenhagen, Denmark. †HvidoSre Hospital, Klampenborg, Denmark. †Medical Department C. Glostrup Hospital, Copenhagen, Denmark. **Department of Medical Physiology C, Panum Institute, University of Copenhagen, Denmark. Journal of Hypertension 7(4):p 287-292, April 1989. Buy Abstract Plasma concentrations of atrial natriuretic factor (ANF) and cyclic guanosine monophosphate (cGMP) were measured in 10 patients with essential hypertension and 10 normotensive controls on the fifth day of a low (50mmol/day), a medium (180mmol/day) and a high (380mmol/day) dietary sodium intake. Plasma ANF and cGMP concentrations were less on the low than on the high sodium intake. Values for ANF on the medium sodium intake were intermediate. In normotensive subjects cGMP concentrations did not differ significantly on the low and the medium sodium intake. As compared with the controls plasma concentrations of cGMP were significantly increased in hypertensive patients on all three levels of sodium intake, while ANF concentrations were identical in the two groups. Since cGMP is a second messenger to ANF the data suggest an increased cellular response to ANF in patients with essential hypertension. © Lippincott-Raven Publishers.