Therapeutic Aspect: PDF OnlyRomanelli Giuseppe; Giustina, Andrea; Agabiti-Rosei, Enrico; Bossoni, Simonetta; Girelli, Angela; Muiesan, Maria L.; Muiesan, Giulio; Giustina, GianniJournal of Hypertension: 1989 - p S312-313 Buy Abstract Physical exercise can induce micro-albuminuria, a urinary albumin excretion rate of 20–200 ng/min, in diabetics without micro-.albuminuria at rest (stage II of diabetic nephropathy). The aim of the present study was to evaluate the acute effects of captopril, an angiotensin converting enzyme (ACE) inhibitor, and nifedipine, a calcium channel blocker, on exercise- induced micro-albuminuria in hypertensive diabetics with stage II nephropathy. Eleven hypertensive World Health Organisation (WHO) stages l–ll non-obese diabetics (five insulin-dependent diabetics, six non-insulin dependent diabetics) underwent five submaximal cycloergometric tests, the first two in basal conditions, the other three after 24-h administration of captopril (25 mg twice a day), placebo (1 tablet twice a day) or nifedipine AR (20 mg twice a day) according to a randomized double-blind design. Our results demonstrate that despite a lower reduction in exercise blood pressure, captopril is more effective than nifedipine in blunting diabetic exercise-induced micro-albuminuria. © Lippincott-Raven Publishers.