Neural and Adrenergic Mechanism: PDF OnlyAttenuation of neurogenic hypertension by chronic converting enzyme inhibitionLongo, Vera L.; Farah, Vera M. M.; Gutierrez, Marco A.; Krieger, Eduardo M. Author Information Heart Institute, University Hospital, Faculty of Medicine, University of São Paulo, São Paulo, Brazil. Journal of Hypertension: Volume 7 - Issue - p S44-45 Buy Abstract We compared the effects produced by acute and chronic administration of captopril in sinoaortic denervated rats. In conscious undisturbed rats acute administration of captopril (10mg/kg intravenously) produced acute transient reductions in mean arterial pressure of 16 and 26%, 6h (mean arterial pressure 148 ± 4mmHg) and 24 h (133 ± 3mmHg) after the sinoaortic denervation, respectively. Chronic captopril treatment (30mg/day orally) produced a permanent attenuation of the hypertension induced by sino-aortic denervation, as shown by a beat-to-beat analysis of arterial pressure for 80 min. The attenuation was 11% (131 ± 7 versus 148 ± 4mmHg) and 24% (103 ± 9 versus 133 ± 3 mmHg) in rats studied 6 and 24 h after the sinoaortic denervation, respectively. Chronic captopril administration produced no alteration in the tachycardia, nor in the heart rate variability of the sinoaortic denervated rats; the latter was lower than that of normotensive rats. These data show that while acute administration of captopril in sinoaortic denervated rats produced a rapid hypotensive response, chronic administration produced a long-lasting attenuation of hypertension, presumably by interference with sympathetic cardiovascular control. © Lippincott-Raven Publishers.
