ORIGINAL ARTICLE: PDF OnlyBlood pressure regulation after deprivation of rapid-eye-movement sleep in ratsMion, Decio Jr; Krieger, Eduardo M. Author Information From the Heart Institute, Faculty of Medicine, University of Sao Paulo POB 11 450, 05499, Sao Paulo, Brazil. Journal of Hypertension: December 1988 - Volume 6 - Issue 4 - p S74-76 Buy Abstract We have shown previously that both sino-aortic denervation and high-renin hypertension in the rat produce a pronounced alteration in the pattern of blood pressure change during sleep; namely from unchanged to an increase in pressure during synchronized sleep, and from a slight increase to a marked decrease during desynchronized sleep. Since rapid-eye-movement sleep deprivation alters the pattern of sleep, we investigated the pattern of arterial pressure changes during sleep in rats submitted to a 48-h period of rapid-eye-movement sleep deprivation (platform technique). The deprived rats showed an increase in the number and length of desynchronized sleep episodes. Unexpectedly, they showed a blood pressure pattern change during synchronized and desynchronized sleep similar to that previously observed in sino-aortic denervated rats and in rats with high-renin hypertension: an increase in arterial pressure during synchronized sleep (+3.16 ± 0.4 versus +0.65 ± 0.65 mmHg in controls) and a decrease during desynchronized sleep (-6.24 ± 0.5 versus +4.22 ± 0.4 mmHg). These data suggest that deprivation of rapid-eye-movement sleep impairs the baroreceptor reflex function during sleep in rats. © Lippincott-Raven Publishers.
