Potassium Influx into Erythrocytes in Essential Hypertension : Journal of Hypertension

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Potassium Influx into Erythrocytes in Essential Hypertension

Bin Talib, Hassan K.; Chipperfield, Alan R.; Semple, Peter F.*

Author Information

From the Department of Physiology, The University, Dundee DD1 4HN, UK and *The Medical Research Council Blood Pressure Unit, Western Infirmary, Glasgow G11 6NT, UK.

Dr Bin Talib's current address is: PO Box 5196, Malla-Aden, Yemen Democratic Republic

Sponsorship: This investigation was supported by a grant and a fellowship to Dr Bin Talib from the WHO.

Requests for reprints to: Dr A.R. Chipperfeild, Department of Physiology, The University. Dundee DDI 4HN, UK.

Date of receipt: 17 February 1984; revised: 18 April 1984.

Journal of Hypertension 2(4):p 405-409, August 1984.

Abstract

 

Sodium plus potassium (Na + K) cotransport in erythrocytes of patients with essential hypertension has mainly been studied elsewhere by measuring net outward frusemide-sensitive Na and K movements. We compared K influx (tracer86 Rubidium) in control subjects and hypertensives who had never previously been treated for hypertension. The cotransport K influx rates in controls and hypertensives were 0.44 ± 0.02 (μmol/ml cells/h; mean ± s.e.; n = 20) and 0.67 ± 0.06 (μmol/ml cells/h; mean ± s.e; n = 23) respectively. The active influxes were 1.03 ± 0.03 and 2.06 ± 0.13 (μmol/ml cells/h; mean ± s.e.) respectively. The variance of both parameters was significantly greater in the hypertensive group but, taking this into account, the differences were significant (P < 0.01).

Journal of Hypertension 2:405-409, 1984

© Lippincott-Raven Publishers.

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