Morphometric Studies on the Rat Renal Papilla of Resistant and Sensitive Strains in Partial Nephrectomy Salt Hypertension : Journal of Hypertension

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Morphometric Studies on the Rat Renal Papilla of Resistant and Sensitive Strains in Partial Nephrectomy Salt Hypertension

Pitcock, James A.; Brown, Peggy S.; Brooks, Bennie; Susic, Dinko*; Kentera, Dusan*; Rapp, John P.†; Muirhead, Eric E.

Author Information

From the Department of Pathology, Baptist Memorial Hospital, and the University of Tennessee Center for the Health Sciences, Memphis, Tennessee 38146, USA, *the Institute for Medical Research, Bulvar JNA10, Yu-11001 Belgrade, Yugoslavia, and the †Department of Medicine, Medical College of Ohio, Toledo, Ohio, USA.

Sponsorship: This study was supported by grant No. USPHS GR HL 19287-08, R073360-30.

Requests for reprints to: Dr James A. Pitcock, Department of Pathology, Baptist Memorial Hospital, 899 Madison Avenue, Memphis, Tennessee 38146, USA

Date of receipt: 29 February 1984; revised: 30 May 1984.

Journal of Hypertension 2(4):p 419-425, August 1984.

Abstract

 

The renomedullary interstitial cell (RIC) was studied morphometrically in the partial nephrectomy-salt (Chanutin-Ferris) model of hypertension. The RIC were compared in four strains of rat, two of them being resistant to the induction of this form of hypertension and two of them being sensitive. The Dahl salt-resistant (R/JR) rat was compared to a commercial Sprague-Dawley (SD) strain, and a Wistar derived strain discovered in Belgrade by Susic and Kentera (WB) was compared to a commercial Wistar strain (W). In both studies, resistance and sensitivity correlated well with the state of the RIC before the experimental procedure, the resistant strain having more numerous and better granulated RIC than the sensitive strain. It may therefore be possible to predict salt-resistance or sensitivity in rats by morphological examination of the RIC.

Journal of Hypertension 2:419-425, 1984

© Lippincott-Raven Publishers.

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