Effect of Ganglionic Blockade with Trimethaphan on Corticosteroid Responses to Metoclopramide in Rhesus Monkeys : Journal of Hypertension

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Effect of Ganglionic Blockade with Trimethaphan on Corticosteroid Responses to Metoclopramide in Rhesus Monkeys

Sowers, James R.; Beck, Frances W.J.; Eggena, Peter

Author Information

From the Neuroendocrinology-Hypertension Laboratories, Richmond Veterans Administration Medical Center, Richmond, Virginia 23249 and Sepulveda Veterans Administration Medical Center, Sepulveda, California 91343, USA.

Sponsorship: This study was funded by a grant from the Veterans Administration

Requests for reprints to: Dr James R. Sowers, Endocrine-Hypertension Division, Veterans Administration Medical Center, Richmond, Virginia 23249, USA.

Date of receipt: 9 December 1983; revised: 29 March 1984.

Journal of Hypertension 2(4):p 367-370, August 1984.

Abstract

 

In order to investigate whether metoclopramide stimulates 18-hydroxycorticosterone and aldosterone production directly by way of the autonomic nervous system, we have examined the effects of ganglionic blockade with trimethaphan on the responses to metoclopramide (200 μg/kg) in rhesus monkeys. Trimethaphan, infused at a rate (200 μg/kg/min) which significantly decreased mean arterial pressure from 122 ± 7 to 62 ± 4 mmHg, did not alter the peak plasma 18-OHB and aldosterone responses to metoclopramide. These results suggest that 18-hydroxycorticosterone and aldosterone responses to metoclopramide occur independently of adrenergic neuronal input.

Journal of Hypertension 2:367-370, 1984

© Lippincott-Raven Publishers.

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