Original Papers: PDF OnlyA Randomized Trial on the Effect of Decreased Dietary Sodium Intake on Blood Pressure in AdolescentsCooper, Richard; Van Horn, Linda; Liu, Kiang; Trevisan, Maurizio; Nanas, Seraphim; Ueshima, Hirotsugu; Larbi, Emmanuel; Yu, Chiu-Sheng; Sempos, Christopher; LeGrady, Dan; Stamler, Jeremiah Author Information From the Department of Community Health and Preventive Medicine, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, Illinois 60611, USA. Sponsorship: This work was supported by NHLBI Grant H126124-02. Additional support was received from the Chicago Heart Association, the AMOCO Foundation (grant to Northwestern Memorial Hospital), Ciba-Geigy, Nabisco Brands, CPC International (Best Foods), Marsteller (Flora Information Service) and the Chicago Health Research Foundation. Dr Liu is a recipient of a Research Career Development Award 1K04 HL00577, NHLBI. Drs Sempos and LeGrady were supported by funds from NHLBI Grant 2T32 HL07113 in a postdoctoral fellowship in Cardiovascular Epidemiology, Biostatistics and Nutrition. Requests for reprints to: Dr R. Cooper, Dept of Community Health and Preventive Medicine, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA. Date of receipt: 6 December 1983; revised: 16 February 1984. Journal of Hypertension 2(4):p 361-366, August 1984. Buy Abstract A randomized crossover trial on the effect of salt restriction on blood pressure was carried out involving 124 adolescents (mean age 16 years). Dietary sodium was reduced from approximately 110 to 45 mEq/24 h for a period of 24 days. Blood pressure was non-significantly lower at the end of the experimental diet for all participants. A slight (0.7 kg), yet statistically significant fall in weight was observed (P < 0.05). Subgroup analysis demonstrated that participants whose body mass index was below the median had a statistically significant fall in systolic blood pressure (P < 0.05); fall in weight and increase in heart rate were also more pronounced in the less obese individuals. It would appear that moderate sodium reduction does not have an overall short-term effect on blood pressure in normotensive adolescents. However, body size as reflected in body mass index may influence blood pressure response to sodium reduction. Journal of Hypertension 2:361-366, 1984 © Lippincott-Raven Publishers.