A Novel Principle for Detection of Systolic and Diastolic Blood Pressure Tested in Man and Rat with Special Reference to its Applicability in Rat Studies : Journal of Hypertension

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A Novel Principle for Detection of Systolic and Diastolic Blood Pressure Tested in Man and Rat with Special Reference to its Applicability in Rat Studies

Jespersen, Lennard T.; Mikkelsen, Erich O.; Lederballe, Ole*; Nyborg, Niels C.B.

Author Information

From the Institute of Pharmacology and *Medical Department I, Aarhus Amtssygehus, University of Aarhus, DK-8000 Aarhus C, Denmark.

Sponsorship: This work was supported by a grant from Kirsten Anthonius's Mindelegat and Løvens Kemiske Fabriks Fond.

Requests for reprints to: Dr Lennard Tang Jespersen, Institute of Pharmacology, University of Aarhus, DK-8000 Aarhus C, Denmark.

Date of receipt: 26 September 1983; revised: 9 July 1984.

Journal of Hypertension 2(4):p 343-347, August 1984.

Abstract

 

A non-invasive procedure for the application of a photodetector method in rat studies to obtain both systolic and diastolic blood pressure measurements is described. The method has been tested against well-established procedures in rats and in human beings and has proved sufficiently fast and reliable for use in long-term studies. Regression analysis of simultaneously obtained invasive versus non-invasive measurements yielded correlation coefficients of 0.99 and 0.98 respectively. Comparison with the Korotkoff principle in human beings yielded correlation coefficients of 0.96 and 0.78 respectively.

Journal of Hypertension 2:343-347, 1984

© Lippincott-Raven Publishers.

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