PATTERNS OF CHILDHOOD CANCER IN CHILDREN ADMITTED TO THE INSTITUTE OF NUCLEAR MEDICINE, MOLECULAR BIOLOGY AND ONCOLOGY (INMO), WAD MEDANI, GEZIRA STATE : Journal of Family and Community Medicine

Secondary Logo

Journal Logo

Original Article

PATTERNS OF CHILDHOOD CANCER IN CHILDREN ADMITTED TO THE INSTITUTE OF NUCLEAR MEDICINE, MOLECULAR BIOLOGY AND ONCOLOGY (INMO), WAD MEDANI, GEZIRA STATE

Haroun, Huda M. MPCH (Khartoum); Mahfouz, Mohamed S. MSc (Gezira); Elhaj, Ahmed M. SCRad Onco, MMED

Author Information
Journal of Family and Community Medicine: May–Aug 2006 - Volume 13 - Issue 2 - p 71-74
  • Open

Abstract

INTRODUCTION

Cancer remains one of the major causes of death in children between the ages of 1 –15 years.1 Pediatric cancers differ markedly from adult cancers in their nature, distribution and prognosis. Pediatric oncologists face unique challenges because treatment with irradiation, surgery and chemotherapy can adversely affect the children's growth and development. The incidence of childhood cancer and type vary greatly throughout the world. Though lower compared with the incidence of some adult cancers, it comes next to accidents as the leading cause of death among children in the developed world.1

The patterns of childhood cancer in America and Europe are almost the same, with leukemia and tumors of the central nervous system accounting for over one-half of the new cases. However, there is a dearth of data on the incidence and patterns of childhood cancer in Africa. Although many papers have been published on this in some African countries,29 reports on the patterns and incidence of childhood cancer in Sudan are very few.

The objective of this study is to determine the patterns of childhood cancer in Gezira State, Central Sudan.

DESIGN AND METHOD

This is a retrospective study using hospital records. The patterns of cancer were studied focusing on the prevalence of tumors according to age, sex, geographic and ethnic distribution and relating the cancer to environmental and genetic causative factors.

All children with cancer, aged one to 15 years diagnosed by means of histological or cytological examination and admitted to the Institute of Nuclear Medicine and Molecular Biology and Oncology from May 1999 – December 2004, were included in the study.

Gezira is the second largest state in Sudan, with an estimated population of 3,962,000 with a 50:50 male to female ratio (49.3:50.7) according to the last population census (1993). It has 13 secondary hospitals, 36 rural hospitals and 150 health centers. Gezira state was considered the richest state in the country before the discovery and extraction of oil. The Institute of Nuclear Medicine, Molecular Biology and Oncology (INMO) which was founded in 1993, has a new department established in 1997 to manage and care for cancer patients in a modern multidisciplinary approach. This is the second oncology centre in Sudan and it caters for patients with cancer from Gezira state and the surrounding states in the central region of Sudan.

RESULTS

The results of this study showed a pattern of childhood cancer in patients admitted to INMO during the period (May 1999 – Dec. 2004). Lymphoma was the most prevalent (42.8%) followed by acute lymphoblastic leukemia (19.8%) and kidney tumors (12.8%).

T1-5
Table 1:
Prevalence of childhood cancer over the period May 1999 – December 2004 at INMO
T2-5
Table 2:
Distribution of childhood cancer according to place of residence and gender
T3-5
Table 3:
Distribution of children according to their tribes
T4-5
Table 4:
Types of cancer by age of children admitted to INMO over the period May 1999-December 2004
T5-5
Table 5:
Association between common types of cancers and child tribes

The prevalence of tumor in children in our study was higher among boys (64.7%) than girls (35.3%).

Most of the children admitted with cancer came from the rural areas (66.1%) compared to 33.9% from urban areas. The distribution of children according to their tribes showed that the majority of them belonged to central Sudan tribes (41.8%), followed by Kordofan and northern Sudan tribes, (both of them recorded 20.3%). Children from the Darfur tribes constituted 14.8%, while those from Eastern Sudan tribes were only 2.7%.

The results showed that lymphoma, acute lymphoblastic leukemia and bone tumor commonly occurred in children above five years of age in contradistinction to kidney tumor and retinoblastoma which commonly occurred in children younger than 5 years. The prevalence of non-Hodgkin lymphoma in males were found to be 65% while it was 35% in females. Male prevalence in Hodgkin lymphoma was 83% while it was 17% in females. There was also a significant association between the children's tribes and the types of cancers at a level of 5%.

DISCUSSION

Although the causes of childhood cancers are largely unknown, a few conditions can be explained with specific chromosomal and genetic abnormalities, and ionizing radiation exposure. Environmental causes have long been suspected by many scientists but have been difficult to determine because it is difficult to identify past exposure levels in children particularly during potentially important periods such as pregnancy or even the time prior to conception. In addition, each of the distinctive types of childhood cancers develops unique clinical course in terms of age, race, gender and many other factors.1

It has been shown that in many developing countries, the reported prevalence of childhood cancer in boys is substantially higher than in girls. The ratio of boys to girls registered with childhood cancer, increased with decreasing gross domestic product and with increasing infant mortality, suggesting that boys are increasingly more likely to be affected than girls with increasing economic disadvantages.10 The ratio of boys to girls in our study is 1.8:1 which agrees with the African trend but differs from the trend in western countries where the female to female ratio is 1:1.1012

The pattern of the cancer in Gezira - Sudan is like other African countries, with lymphoma as the commonest followed by acute lymphoblastic leukemia and kidney tumor. This was also the pattern found in a study conducted in Khartoum in the early nineties.1316

The distribution of the most common three cancers according to age and gender in our study, is in consonance with international trends for lymphoma as a common cancer in children aged more than five years, with non-Hodgkin lymphoma being twice more common in males than in females, while Hodgkin is five times more common in males than in females.

In this study, acute lymphoblastic leukemia differed from the international trend in that it was more common among the children aged more than five years. However, the gender distribution was similar to the international pattern which has females and males equally affected.

The prevalence of kidney tumors as evident in our study is in accord with the international pattern which shows that the tumor is prevalent in children less than 5 years of age with slight difference in male to female ratio 1.7: 1.

There was a significant relationship of the prevalence of different cancers in relation to the different Sudan tribes.

CONCLUSION

In this study it was evident that the:

  1. Patterns of cancer in Gezira State is like other African patterns but different from those of western countries.
  2. Lymphoma is the most common cancer in Gezira State, with males three times more affected than females. Children above five years of age were shown to be the most commonly affected.
  3. In contrast to western countries leukemia is more prevalent in children above five years of age.

RECOMMENDATIONS

  1. There is a need for research to determine the annual incidence of different cancers in children in Gezira and determine mortality and five year survival rates.
  2. A detailed study of environmental risk factors is necessary since Gezira state has the largest agricultural scheme in Africa and Middle East.

REFERENCES

1. . American Cancer Society Cancer Facts and Figures 2005 reviewed on March 29, 2005. accessed at http://www.cancer.org
2. Ojesina Al, Akang EE, Ojemakinde KO. Decline in the frequency of Burkitt's lymphoma relative to other childhood malignancies in Ibadan, Nigeria Ann Trop Paediatr. 2002;22(2):159–63
3. Makata AM, Toriyama K, Kamidigo NO, Eto H, Itakura H. The pattern of pediatrics solid malignant tumors in western Kenya, east Africa, 1979-1994: an analysis based on histopathologic study Am J Trop Med Hyg. 1996;54(4):343–7
4. Chintu C, Athale UH, Patil PS. Childhood cancer in Zambia before and after HIV epidemic Arch Dis Child. 1995;73(2):100–4
5. Mukiibi JM, Banda L, Liomba NG, Sungani FC, Parkin DM. Spectrum of childhood cancer in Malawi 1985-1993 East Afr Med J. 1995;72(1):25–9
6. Akhtar SS, Abu Bakr MA, Dawi SA, Hug IU. Cancer in Libya – a retrospective study (1981-1985) Afr J Med Sci. 1993;22(1):17–24
    7. Fischer PR, Ahuka Lo, Wood PB, Lucas S. Malignant tumors in children of northeastern Zaire. A comparison of distribution pattern Clin Pediatr. 1990;29(2):95–8
    8. Obioha FI, Kaine WN, Ikerionwu SE, Obi GO, Ulasi TO. The pattern of childhood malignancy in eastern Nigeria Ann Trop Paediatr. 1989;9(4):261–5
    9. Bella AE. The pattern of malignant disease in children presenting to Khartoum Hospital (dissertation) Khartoum hospital: Khartoum University. 1983
    10. Pearce MS, Parker L. Childhood cancer registrations in the developing world: still more boys than girls Int J Cancer. 2001;91(3):402–6
    11. Plesko I, Somogyi J, Dimitrova E, Kramaroki. Descriptive epidemiology of childhood malignancy in Slovakia Neoplasm. 1989;36(2):233–43
      12. Gonzalez JR, Fernandez E, de Toledo Js, Galceran J, Peris M, Gispe BJM. Trends in childhood cancer incidence and mortality in Catalonia Spain 1975-1998 Eur J Cancer Prev. 2004;13(1):47–51
      13. Makata AM, Toriyama K, Kamidigo NO, Eto H, Itakura H. The pattern of pediatric solid malignant tumors in western Kenya, east Africa, 1979-1994: an analysis based on histopathological study Am J Trop Med Hyg. 1996;54(4):343–7
      14. Tijani SO, Elesha SO, Banjo AA. Morphological patterns of paediatric solid cancer in Lagos, Nigeria West Afr Med J. 1995;14(3):174–8
        15. Levi F, Lavecchiac, Lucchini F, Negri E, Boyle P. Patterns of childhood cancer mortality: America, Asia and Kenya Eur J Cancer. 1995;31A(5):771–82
        16. Mukiibi JM, Nyrenda CM, Adewuyi JO, Mzula EL, Magombo ED, Mibvundula EM. Leukaemia at Queen Elizabeth Central Hospital in Blantype, Malawi East Afr Med J. 2001;78(7):349–54
        Keywords:

        Leukemia; Lymphoma; Pattern; Prevalence; Cancer

        © 2006 Journal of Family and Community Medicine | Published by Wolters Kluwer – Medknow