Analysis of the serum levels of CAT and MDA in vitilgo patients and controls was performed and it was found that the serum level of CAT was lower and the serum level of MDA was higher in patients than in controls (P≤0.001). However, no correlations were found between serum levels of CAT and MDA and age of patients, disease extent, duration, and activity (Table 7).
In the same time, the results of the two most recent meta-analyses were contradictory 16,17. The meta-analysis is used to provide an estimate of the genetic risk effect with a reduced uncertainty. It is also used to explore the trend of risk effect as evidence accumulates 34,35. The meta-analysis by Lu et al.16 included seven studies with 1531 vitiligo patients and 1608 controls. They documented that the CT genotype may be a risk factor for susceptibility and the CC genotype may be protective against the development of vitiligo in western Europeans. Moreover, they suggested that 389 C/T polymorphisms in the CAT gene are not associated with the risk for vitiligo in Asians and Turkish populations. They observed that the positive association was with people from Western Europe and the negative association was with people from Eastern Europe (i.e. may include Asian populations). They concluded that difference in ethnicity, life habit, and geographical environment may explain the large difference between various studies.
Allele and genotype frequency showed similar and different distribution between Egyptians and other populations and even among Egyptian population. This can be explained by the difference in sample size, difference in disease phenotype, difference in the technique of SNP typing, and difference in the ethnicity and genetic background of the Egyptians. The analysis of Y-chromosome gene pool in the modern Egyptian population was performed by Manni et al.37. They confirmed the mixed ethnicity of Egyptians and the presence of a mixture of European, Middle Eastern, and African genetic characteristics in Egyptians genetics. In the same time, a more specific analysis of Y-chromosome haplotypes was performed in Lower Egypt, Upper Egypt, and Nubia 37–39. Different distribution of different haplotypes was found between people living in Upper Egypt and those living in Lower Egypt (Delta region of the present study). This finding confirms the different ethnic origins of both Egyptian populations.
The serum level of CAT was lower and the serum level of MDA was higher in the studied sample of Egyptian vitiligo patients (P≤0.001). No correlations and relations were found between the CAT genotypes and serum levels of these markers or age of patients, disease extent, duration and activity. However, it is observed that the lowest level of CAT was with TT genotype of CAT 389 and the highest level of MDA was with AA genotype of CAT –89 (Tables 5–7).
There are no conflicts of interest.
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