Determining in vivo biomechanical properties of the cornea with an ocular response analyzer

Abstract

Purpose: 

To study the results of an ocular response analyzer (ORA) to determine the biomechanical properties of the cornea and their relationship to intraocular pressure (IOP).

Setting: 

Reichert Inc., Depew, New York, USA.

Methods: 

The ORA (Reichert) makes 2 essentially instantaneous applanation measurements that permit determination of corneal and IOP effects.

Results: 

Measurements of several populations indicate that corneal hysteresis, a biomechanical measure, varied over a dynamic range of 1.8 to 14.6 mm Hg and was only weakly correlated with corneal thickness (r² = 0.12); this is related to the observation that some subjects with relatively thick corneas have less-than-average corneal hysteresis. Corneal hysteresis changes diurnally, presumably as a result of hydration changes. Keratoconus, Fuchs' dystrophy, and post-LASIK patients demonstrated low corneal hysteresis.

Conclusion: 

The corneal hysteresis biomechanical measure may prove valuable for qualification and predictions of outcomes of refractive surgery and in other cases in which corneal biomechanics are important.

In Brief

The ocular response analyzer determines biomechanical properties of the cornea and the IOP by making 2 essentially instantaneous applanation measurements that permit determination of corneal and pressure effects. Measurements indicate that a new corneal biomechanical measure called corneal hysteresis varies over a dynamic range and is only weakly correlated with corneal thickness.