To compare outcomes in patients that underwent cataract extraction with implantation of non-diffractive extended depth of focus (ND-EDOF; Alcon Acrysof Vivity) or neutral aspheric monofocal (Bausch & Lomb enVista) intraocular lenses (IOL).
Academic medical center.
Prospective, single-center, double-arm, patient and assessor masked, randomized controlled trial.
Patients were randomized to receive either a ND-EDOF or monofocal IOL in both eyes, targeted for emmetropia. Uncorrected and corrected distance (CDVA), distance-corrected intermediate (DCIVA), distance-corrected near (DCNVA), level of spectacle independence, and severity of photic phenomena were assessed 3 months after surgery.
56 patients were enrolled, of which 24 in the ND-EDOF group and 27 in the monofocal group completed follow-up. The binocular mean CDVA, DCIVA and DCNVA’s were 20/20, 20/19, and 20/21 for the ND-EDOF lens and 20/18 (P = .188), 20/31 (P < .001), and 20/30 (P = .004) for the monofocal IOL, respectively. At intermediate, 88% of the ND-EDOF vs. 30% of the monofocal patients had a binocular DCIVA of 20/25 or better (P < .001). Moderate or severe glare occurred in 20.8% of ND-EDOF vs. 7.4% of monofocal patients (P = .228), whereas moderate or severe halos occurred in 16.7% of ND-EDOF vs. 11.1% of monofocal patients (P = .697).
The ND-EDOF and monofocal IOLs provided similarly excellent distance vision. Patients implanted with the ND-EDOF IOL had 2 more lines of vision at both intermediate and near, and a greater proportion reported spectacle independence. Most patients in both groups reported low severity of photic phenomena.