Relative efficacy of intracameral moxifloxacin injection methods

Abstract

Purpose: 

To determine the amount of moxifloxacin remaining in the anterior chamber (AC), immediately after its injection using 3 current injection methods, assuming mixing and fluid exchange with the AC contents during injection of the drug, and to determine the most desirable injection method.

Setting: 

Department of Ophthalmology and Vision Sciences and Institute of Biomedical Engineering, University of Toronto, Toronto, Canada.

Design: 

Mathematical modeling.

Methods: 

Mathematical modeling using first-order mixing methods were used to assess mixing.

Results: 

The Kaiser method of injecting 0.5 mL × 100 μg/0.1 mL does not achieve the desired 500 μg level of moxifloxacin in the AC. The “straight from the bottle” method of injecting 0.1 mL × 500 μg/0.1 mL is fraught with potential error, yielding a relatively unreliable final amount in the AC. Injecting 0.5 to 0.6 mL × 150 μg/0.1 mL yields a result closest to the desired goal.

Conclusions: 

Based on the calculation, the most accurate of current methods to deliver 500 μg moxifloxacin intracamerally is the method of 150 μg/0.1 mL × 0.5 to 0.6 mL.

In Brief

When injecting prophylactic intracameral moxifloxacin, the method of 0.5 to 0.6 mL × 150 μg/0.1 mL yields closest to the desired 500 μg retained in the AC, when considering mixing during injection.