Articles: PDF OnlyUse of topical nonsteroidal anti-inflammatory drugs in excimer laser photorefractive keratectomyArshinof, Steve M.D., F.R.C.S.C.1; D'Addario, Denise M.D.; Sadler, Christine B.Sc.Phm.; Bilotta, Rose M.H.Sc.; Johnson, Mark T. B.Sc.Author Information 1Reprint requests to Steve Arshinof M.D., F.R.C.S.C., 2115 Finch Avenue West, Suite 316, Downsview, Ontario, Canada M3N 2V6. Presented at the Symposium on Cataract, IOL and Refractive Surgery, San Diego, April 1992. Update presented at the 3rd American-International Congress on Cataract, IOL and Refractive Surgery, Seattle, May 1993. The authors have no proprietary or financial interest in any of the products discussed or their manufacturers. The Toronto Eye Foundation provided partial support of this project. Journal of Cataract & Refractive Surgery: March 1994 - Volume 20 - Issue - p 216-222 doi: 10.1016/S0886-3350(13)80756-0 Buy Metrics Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) produce potent analgesic, antipyretic, and anti-inflammatory effects. We studied postoperative pain in 97 consecutive patients having photorefractive keratectomy (PRK) by an excimer laser with different topical NSAID protocols. Treatment with topical homatropine hydrobromide, either diclofenac sodium (Voltaren Ophthalmic®) or ketorolac tromethamine (Acular®), and a soft contact lens was most effective in achieving post-PRK analgesia. We also studied post-PRK myopic regression in 68 consecutive patients and found that flurbiprofen sodium (Ocufen®), when added to topical steroid protocols, significantly reduced myopic regression for one year postoperatively more than steroids alone or steroids and diclofenac sodium. Diclofenac, used with topical steroids, had less of an additive effect on myopic regression than did flurbiprofen. Topical NSAIDs are useful adjuncts to PRK therapy, both to eliminate postoperative pain and to control post-PRK myopic regression. © Williams & Wilkins 1994. All Rights Reserved.