Scientific ReviewReview of Trials on Exercise-Based Rehabilitation Interventions Following Acute Decompensated Heart Failure OBSERVATIONS FROM THE WHO INTERNATIONAL CLINICAL TRIALS REGISTRY PLATFORMBabu, Abraham Samuel PhD; Arena, Ross PhD, FAHA; Satyamurthy, Akhila MPT; Padmakumar, Ramachandran DM; Myers, Jonathan PhD; Lavie, Carl J. MDAuthor Information Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Karnataka, India (Dr Babu and Ms Satyamurthy); Healthy Living for Pandemic Event Protection (HL-PIVOT) Network, Chicago, Illinois (Drs Babu, Arena, Myers, and Lavie); Department of Physical Therapy, University of Illinois at Chicago (Dr Arena); Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Karnataka, India (Dr Padmakumar); Department of Cardiology, Veterans Affairs Palo Alto Health Care System/Stanford University, Palo Alto, California (Dr Myers); and Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School—The University of Queensland School of Medicine, New Orleans, Louisiana (Dr Lavie). Correspondence: Abraham Samuel Babu, PhD, Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal—576104, Karnataka, India ([email protected]). Ms Akhila Satyamurthy is supported by the Junior Research fellowship program from the Indian Council of Medical Research, Government of India through the research grant 5/4/1-9/2019-NCD-II. The authors declare no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.jcrpjournal.com). Journal of Cardiopulmonary Rehabilitation and Prevention: July 2021 - Volume 41 - Issue 4 - p 214-223 doi: 10.1097/HCR.0000000000000583 Buy SDC Metrics AbstractIn Brief Purpose: Cardiac rehabilitation is an important intervention for patients with heart failure. However, its clinical application in acute decompensated heart failure (ADHF) remains underutilized with limited research available. An assessment of current research in this area will help guide future investigations. The aim of this review is to summarize the current research focusing on rehabilitation interventions following recovery from ADHF. Review Methods: A systematic search was carried out on all trials registered in the clinical trial registry database of the World Health Organization—International Clinical Trial Registry Platform (WHO-ICTRP). Studies focusing on ADHF and utilizing any exercise and rehabilitation-based intervention were included. Results: A majority of 11 trial protocols, including 3827 participants with low ejection fraction (<40%), were identified from the WHO-ICTRP database. Majority of the protocols (64%) focused on exercise-based interventions with approximately one-quarter (29%) focusing on neuromuscular electrical stimulation and one on noninvasive ventilation during exercise. Irrespective of the mode of exercise, all protocols employed low-moderate intensity training with outcomes focusing on physical function and quality of life. Conclusion: Studies on rehabilitative interventions for ADHF are still in their early stages. More research is needed using innovative methodologies and testing for feasibility and fidelity. Exercise-based cardiac rehabilitation following recovery of acute decompensated heart failure holds promise as a therapeutic intervention. Currently, only a few registered trials (n = 11) and published studies (n = 14) exist in this area. Greater importance is to be placed on research in this area. © 2021 Wolters Kluwer Health, Inc. All rights reserved.