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Short-Duration High-Intensity Interval Exercise Training Is More Effective Than Long Duration for Blood Pressure and Arterial Stiffness But Not for Inflammatory Markers and Lipid Profiles in Patients With Stage 1 Hypertension

Aghaei Bahmanbeglou, Neda, PhD; Ebrahim, Khosrow, PhD; Maleki, Majid, MD, PhD; Nikpajouh, Akbar, MD, PhD; Ahmadizad, Sajad, PhD

Journal of Cardiopulmonary Rehabilitation and Prevention: January 2019 - Volume 39 - Issue 1 - p 50–55
doi: 10.1097/HCR.0000000000000377
Exercise Physiology

Purpose: The present study compared the effects of 2 different high-intensity interval training (HIIT) protocols on arterial stiffness, lipid profiles, and inflammatory markers in hypertensive patients.

Methods: Thirty hypertensive (stage 1) patients, aged 48.0 ± 3.2 yr, were randomly allocated to the short-duration HIIT (SDHIIT, n = 10), long-duration HIIT (LDHIIT, n = 10), and control (n = 10) groups. After a 2-wk preparatory phase of continuous mild training, patients in the SDHIIT group performed 8 wk of HIIT including 27 repetitions of 30-sec activity at 80% to 100% of

O2peak interspersed with 30-sec passive/active (10%-20% of

O2peak) recovery. Patients in the LDHIIT group performed 8 wk of HIIT, 32 min/session including 4 repetitions of 4-min activity at 75% to 90% of

O2peak interspersed with 4-min passive/active (15%-30% of

O2peak) recovery. Blood pressure (BP), pulse wave velocity (PWV), inflammatory markers, and lipid profiles were measured before and after training.

Results: Significant (P < .05) reductions in systolic blood pressure and PWV were found following 2 training protocols, though, only the changes in PWV following the SDHIIT were significantly different than those in the LDHIIT and control groups. Interleukin-6 and triglycerides decreased and interleukin-10 increased significantly (P < .01) following both HIIT programs, whereas the differences between the 2 training protocols were not statistically significant. C-reactive protein and lipids did not change significantly following HIIT.

Conclusions: Performing HIIT improves systolic blood pressure and inflammatory markers in patients with stage 1 hypertension irrespective of the HIIT intensity and duration, and PWV improvement is intensity related.

To compare the effects of different high-intensity interval training (HIIT) protocols on arterial stiffness and inflammatory markers, 30 hypertensive patients were assigned to 8 wk of short-duration (30 sec) or long-duration (4 min) HIIT or control. HIIT improves blood pressure and inflammatory markers, irrespective of intensity and duration, whereas improvement in arterial stiffness is intensity related.

Department of Biological Sciences in Sport and Health, Faculty of Sports Sciences and Health, Shahid Beheshti University, Tehran, Iran (Drs Aghaei Bahmanbeglou, Ebrahim, and Ahmadizad); and Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran (Drs Maleki and Nikpajouh).

Correspondence: Sajad Ahmadizad, PhD, Department of Biological Sciences in Sport and Health, Faculty of Sports Sciences and Health, Shahid Beheshti University, Velenjak, Tehran, Iran 1983963113 (

The authors declare no conflicts of interest.

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