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Effect of a Lifestyle Therapy Program Using Cardiac Rehabilitation Resources on Metabolic Syndrome Components

Rodriguez-Escudero, Juan P. MD; Somers, Virend K. MD, PhD; Heath, Amy L. BS; Thomas, Randal J. MD, MSc; Squires, Ray W. PhD; Sochor, Ondrej MD, PhD; Lopez-Jimenez, Francisco MD, MSc

Journal of Cardiopulmonary Rehabilitation and Prevention: November/December 2013 - Volume 33 - Issue 6 - p 360–370
doi: 10.1097/HCR.0b013e3182a52762
Cardiac Rehabilitation

PURPOSE: To assess the effect of a lifestyle therapy program using cardiac rehabilitation (CR) resources for patients at risk for metabolic syndrome (MetS).

Methods: We designed a cardiometabolic program (CMP) using CR facilities and resources. We compared MetS components of 240 patients classified as either obese (body mass index, ≥30 kg/m2) or hyperglycemic (fasting glucose, >100 mg/dL): 58 enrolled and completed the CMP, 59 signed up for the CMP but never attended or dropped out early (control 1) but had followup data, and 123 did not sign up for the CMP (control 2).

Results: The CMP group showed a significant improvement at 6 weeks in waist circumference, body weight, diastolic blood pressure, and total cholesterol. At 6 months, fasting glucose also improved. In contrast, improvements in control 1 and control 2 were modest at best. Comparing the 6-month changes in the CMP group versus control 1 group, those in the CMP had pronounced weight loss (−4.5 ± 5 kg vs −0.14 ± 6 kg; P < .001), decreased systolic blood pressure (−1.1 ± 17 mm Hg vs +9.6 ± 20 mm Hg; P = .004), and decreased diastolic blood pressure (−4.6 ± 11 mm Hg vs +3.4 ± 15 mm Hg; P = .002). Similarly, comparing CMP group versus control 2 group, body weight (−4.5 ± 5 kg vs −0.9 ± 3 kg; P < .001) and diastolic blood pressure (−4.6 ± 11 mm Hg vs −0.7 ± 9 mm Hg; P = .02) declined in the CMP group.

Conclusion: A lifestyle therapy program using resources of a CR program is effective for individuals who have or are at risk for MetS, although enrollment and completion rates are low.

We created a cardiometabolic program by using facilities and resources of a cardiac rehabilitation program. A lifestyle therapy program using this approach is effective for individuals with or at risk for metabolic syndrome, although enrollment and completion rates are low.

Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota (Drs Rodriguez-Escudero, Somers, Thomas, Squires, Sochor, and Lopez-Jimenez and Ms Heath); and Department of Cardiovascular Diseases, International Clinic Research Center, St Anne's University Hospital Brno, Brno, Czech Republic (Dr Sochor).

Correspondence: Francisco Lopez-Jimenez, MD, MSc, Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (

The authors declare no conflicts of interest.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins