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Genetic Profile of Clear Cell Odontogenic Carcinoma

Carinci, Francesco MD*; Volinia, Stefano PhD; Rubini, Corrado MD; Fioroni, Massimiliano MD§; Francioso, Francesca PhD; Arcelli, Diego PhD; Pezzetti, Furio PhD; Piattelli, Adriano MD§

Journal of Craniofacial Surgery: May 2003 - Volume 14 - Issue 3 - p 356-362
Scientific Foundations
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In the head and neck region, clear cell tumors are usually derived from salivary glands, odontogenic tissues, and metastasis. The World Health Organization has classified clear cell odontogenic tumor among benign tumors, but it is now recognized as a more sinister lesion, and current opinion is that it should be designated as a carcinoma. It is characterized by aggressive growth, recurrences, and metastasis. By using complementary DNA microarrays, several genes in clear cell odontogenic tumor were identified that are differentially regulated when compared with non-tumor tissue. In conclusion, the first genetic profiling of clear odontogenic carcinoma is reported. DNA microarrays can potentially help in identifying some genes whose products could be disease-specific targets for cancer therapy as well as a tool for better classifying odontogenic tumor.

Ferrara, Italy

Ancona, Italy

Chieti, Italy

Bologna, Italy

From the Departments of *Maxillofacial Surgery and Morphology and Embryology, University of Ferrara, Ferrara; Department of Pathology, University of Ancona, Ancona; §Dental Clinic, University of Chieti, Chieti; and Institute of Histology, Institute of Histology and Center of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy.

Address correspondence to Dr Carinci, ENT Clinic, University of Ferrara, Arcispedale S. Anna, Corso Giovecca, 203, 44100 Ferrara, Italy; e-mail: crc@unife.it

© 2003 Mutaz B. Habal, MD