Scientific FoundationInfluence of Smartphone Wi-Fi Signals on Adipose-Derived Stem CellsLee, Sang-Soon MD, PhD*; Kim, Hyung-Rok MD*; Kim, Min-Sook MS*; Park, Sanghoon PhD†; Yoon, Eul-Sik MD, PhD*; Park, Seung-Ha MD, PhD*; Kim, Deok-Woo MD, PhD* Author Information From the *Department of Plastic and Reconstructive Surgery, Korea University Medical Center; and †Korea Electronics Technology Institute. Received July 27, 2013. Accepted for publication February 17, 2014. Address correspondence and reprint requests to Dr. Deok-Woo Kim, Department of Plastic and Reconstructive Surgery, Korea University Ansan Hospital, 123 Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi-do 425-707, Republic of Korea; E-mail: [email protected] The authors report no conflicts of interest. The Journal of Craniofacial Surgery 25(5):p 1902-1907, September 2014. | DOI: 10.1097/SCS.0000000000000939 Buy Metrics Abstract The use of smartphones is expanding rapidly around the world, thus raising the concern of possible harmful effects of radiofrequency generated by smartphones. We hypothesized that Wi-Fi signals from smartphones may have harmful influence on adipose-derived stem cells (ASCs). An in vitro study was performed to assess the influence of Wi-Fi signals from smartphones. The ASCs were incubated under a smartphone connected to a Wi-Fi network, which was uploading files at a speed of 4.8 Mbps for 10 hours a day, for a total of 5 days. We constructed 2 kinds of control cells, one grown in 37°C and the other grown in 39°C. After 5 days of Wi-Fi exposure from the smartphone, the cells underwent cell proliferation assay, apoptosis assay, and flow cytometry analysis. Three growth factors, vascular endothelial growth factor, hepatocyte growth factor, and transforming growth factor-β, were measured from ASC-conditioned media. Cell proliferation rate was higher in Wi-Fi–exposed cells and 39°C control cells compared with 37°C control cells. Apoptosis assay, flow cytometry analysis, and growth factor concentrations showed no remarkable differences among the 3 groups. We could not find any harmful effects of Wi-Fi electromagnetic signals from smartphones. The increased proliferation of ASCs under the smartphone, however, might be attributable to the thermal effect. © 2014 by Mutaz B. Habal, MD.