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Poly D,L-Lactide-Co-Glycolic Acid Grafting Material in Sinus Lift

Mastrangelo, Filiberto, DDS, PhD*; Quaresima, Raimondo, ENG*; Sebastianelli, Ilaria, DDS; Dedola, Alberto, DDS; Kuperman, Shiri, DMD§; Azzi, Lorenzo, DDS, PhD; Mortellaro, Carmen, MD, DDS||; Muttini, Aurelio, VET**; Mijiritsky, Eitan, DMD††

Journal of Craniofacial Surgery: June 2019 - Volume 30 - Issue 4 - p 1073–1077
doi: 10.1097/SCS.0000000000005067
Clinical Studies

The poly D,L-lactide-co-glycolic acid (PLGA) is a copolymer used in many therapeutic devices for its high rates of biodegradability and biocompatibility. The principal aim of the research was to evaluate the new bone formation, after 16 (T1) and 28 weeks (T2), in sheep maxillary sinus lift in vivo model using PLGA.

Computerized tomography analysis, X-ray microanalysis, and scanning electron microscope analysis of secondary electrons (SE) and the backscattered electrons (BSE) of the samples were detected.

After 28 weeks, the computed tomography analysis showed a 22% increase of UH density in the grafting areas. The X-ray microanalysis of the samples showed calcium and phosphorus increase at T1 and T2 follow-up period and the carbon and oxygen concentration decrease. The SE evaluation showed a rapid superficial resorption of the biomaterials at T1 and a completely bone reorganization of biomaterial at T2. The BSE analysis confirmed the SE data and showed the direct and intimate contact between bone and PLGA with a higher calcification in T2 compared to T1.

Certainly, still other experiments and a larger number of samples will be necessary to be analyzed to determine the behavior of the PLGA in the bone regeneration; however, the PLGA used in maxillary sinus lift animal model, seem to promote new bone formation that continues increase at 28 weeks after grafting.

*Clinical and Experimental Medicine Department, University of Foggia, Foggia

Department of Chemistry, Chemical Engineering and Materials University of L’Aquila, L’Aquila

Pescara, Italy

§Tel Aviv, Israel

Department of Medicine and Surgery, University of Insubria, Varese

||Department of Medical Science, University of Eastern Piedmont, Novara

**Department of Comparative Biomedical Sciences, University of Teramo, Teramo, Italy

††Department of Otolaryngology, Head and Neck and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Address correspondence and reprint requests to Filiberto Mastrangelo, MD, DDS, Department of Clinical and Experimental Medicine, University of Foggia, Via Luigi Rovelli no 48, 71122 Foggia, Foggia, Italy; E-mail:,

Received 13 May, 2018

Accepted 17 July, 2018

The authors report no conflicts of interest.

© 2019 by Mutaz B. Habal, MD.