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Histologic and Radiographic Characteristics of Bone Filler Under Bisphosphonates

Yifat, Manor, DMD*; Hila, Elias, DMD; Avraham, Hirshberg, MD, DMD; Inchingolo, Francesco, MD, DMD§; Mortellaro, Carmen, MD, DDS; Peleg, Oren, DMD||; Mijiritsky, Eithan, DMD||

Journal of Craniofacial Surgery: June 2019 - Volume 30 - Issue 4 - p 1085–1088
doi: 10.1097/SCS.0000000000005517
Clinical Studies
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Background: Dental implants and bone augmentation are well-established procedures used for oral rehabilitation. There is an increasing interest in biological mediators used topically for prevention of bone resorption maybe enhancement of osseointegration of dental implants. The purpose of the manuscript is to describe preliminarily the effect of bisphosphonates on the ossification pattern of bone grafts in a rat model.

Material and Methods: Twenty Wistar-derived male rats were divided into 2 groups study and control. Bone substitute was added to mandibular defects and was covered by a resorbable collagen membrane. In the study group, the membrane was soaked with bisphosphonates suspension. In the control group, the membrane was soaked with saline solution. Radiographic and histomorphometric evaluation were performed.

Results: Radiographically, it was found that bone density was significantly higher in the study group. Histomorphometric analysis revealed a trend of higher bone volume fraction along with reduced bone substitute volume fraction in the study group, and increased number of osteoclasts and blood vessels in the control group.

Conclusions: Within the limitations of our study it was found that there is a trend of increasing bone quantity and radiographic bone density by application of bisphosphonates.

*Department of Oral and Maxillofacial Surgery, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel-Aviv University and Department of Oral and Maxillofacial Surgery, Assaf Harofe Medical Center Zriffin

The Maurice and Gabriela Goldschleger School of Dental Medicine

Department of Oral Pathology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel-Aviv University, Tel-Aviv, Israel

§Interdisciplinary Department of Medicine/University of Bari

Department of Medical Science, University of Eastern Piedmont, Novara, Italy

||Head and Neck Maxillofacial Surgery, Department of Otoryngology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Address correspondence and reprint requests to Manor Yifat, DMD, Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tel-Aviv University, Haim Levanon St no 30, Tel-Aviv, Israel; E-mail: yifatmanor@gmail.com

Received 24 December, 2018

Accepted 9 February, 2019

The authors report no conflicts of interest.

© 2019 by Mutaz B. Habal, MD.