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Olfactory Bulb Microstructural Changes in Patients With Nasal Septum Deviation

Aslan, Kerim, MD*; Saglam, Dilek, MD; Gunbey, Hediye Pinar, MD; Incesu, Lutfi, MD*

doi: 10.1097/SCS.0000000000005479
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Objective: The aim of this study is to assess the microstructural changes to the olfactory bulb (OB) in patients with nasal septum deviation (NSD) using diffusion tensor imaging and to research the association between these changes and the degree of NSD.

Methods: Ninety-six patients with NSD (46 males, 50 females) who received diffusion tensor imaging were assessed by 2 independent readers. The patients were separated into 3 groups according to the NSD angle. The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of the ipsilateral and contralateral OB were measured in all NSD patients by region of interest.

Results: According to deviation side, there was significant difference between the right (R) and left (L) OB FA and ADC values across the 3 groups. In patients with left- and right- sided NSD, FA and ADC values for the left and right OB were significantly different between groups 1 and 3, and groups 2 and 3. There was negative correlation between L-FA (r = −0.481, P = 0.001; r = −0.496, P = 0.001) and R-FA (r = −0.705, P = 0.001; r = −0.286, P = 0.02) versus age and deviation angle. However, there was positive correlation between L-ADC versus age and deviation angle (r = 0.493, P = 0.001; r = 0.482, P = 0.001), as well as positive correlation between R-ADC versus age (r = 0.646, P = 0.001).

Conclusion: This is the first study showing ADC increase and FA decrease associated with axonal damage and microstructural integrity loss based on the side of deviation in NSD patients. It has also shown that this abnormality is directly proportional with NSD degree.

*Department of Radiology, Ondokuz Mayis University Faculty of Medicine, Samsun

Department of Radiology, Health Sciences University Malatya Training and Research Hospital, Malatya

Department of Radiology, Health Sciences University Kartal Lütfi Kirdar Training and Research Hospital, Istanbul, Turkey.

Address correspondence and reprint requests to Kerim Aslan, Assistant Professor of Radiology, Department of Radiology, Ondokuz Mayis University Faculty of Medicine, Kurupelit, Samsun, Turkey; E-mail: mdkerim@hotmail.com

Received 16 January, 2019

Accepted 13 February, 2019

The authors report no conflicts of interest.

© 2019 by Mutaz B. Habal, MD.