As online media acquires increased utilization as a means of disseminating scientific research, Altmetric analyses are useful to identify socially impactful publications and their characteristics. Accordingly, the objective of this investigation was to determine the most mentioned articles online regarding craniofacial surgery and compare these articles with their most cited counterparts. Using the Web of Science database, 7097 craniofacial surgery publications were identified. Altmetric Attention Score (AAS) and average citations per year (ACpY) were extracted, and articles were ranked by their social and scientific impact. Descriptive, comparative, and correlational analyses were performed to examine characteristics including AAS, ACpY, country of origin, journal, open access (OA) status, publication year, study design, and topic. The average AAS of the 50 most mentioned articles was 83.68 (SD±107.40), and the average citation count of the 50 most cited articles was 76.38 (SD±35.15). OA status was significantly more prevalent among the most mentioned articles (24.0%) relative to all articles (10.72%) and the most cited articles (4.0%). The most mentioned and the most cited articles primarily originated from the United States (64.0% and 38.0%, respectively), discussed topics related to the medical and surgical management of patients (48.0% and 58.0%, respectively), and were systematic reviews (16.0% and 28.0%, respectively). However, there was significantly more geographic diversity in the latter cohort. In summary, this comparative examination reveals important differences between the most mentioned and most cited articles, highlighting the distinct utility of AAS and citation count when evaluating research impact.