Original ArticlesThe Role of Staged Cryosurgery and Three-Dimensional Computed Tomography Integrated Navigation System in the Surgical Management of Severe Involvement of Craniofacial Polyostotic Fibrous DysplasiaYildiz, Kemalettin MD∗; Dündar, Tolga Turan MD†; Abdallah, Anas MD†; Mehdizade, Turan MD∗; Güneren, Ethem MD∗; Canter, Halil Ibrahim MD‡Author Information ∗Department of Plastic, Reconstructive and Aesthetic Surgery, Bezmialem Vakif University †Department of Neurosurgery, Bezmialem Vakif University ‡Plastic, Reconstructive and Aesthetic Surgeon, Private Practice, Kadikoy, Istanbul, Turkey. Address correspondence and reprint requests to Kemalettin Yildiz, MD, Department of Plastic Reconstructive and Aesthetic Surgery, Bezmialem Vakif University, Vatan Street, 34093 Fatih, Istanbul, Turkey; E-mail: firstname.lastname@example.org Received 9 December, 2019 Accepted 8 January, 2020 The authors have no conflicts of interest to disclose. Journal of Craniofacial Surgery: June 2020 - Volume 31 - Issue 4 - p 1006-1009 doi: 10.1097/SCS.0000000000006348 Buy Metrics Abstract Fibrous dysplasia (FD) is a developmental bone disorder caused by the hamartamatous proliferation of bone-forming cells. A 29-year-old male patient with diagnosis of FD was admitted to our clinic with the symptoms of severe craniomaxillofacial involvement of FD beginning from last year. Neurological examination revealed diplopia, horizontal nystagmus, conductive hearing loss, and partial vision loss. In his medical history, it was reported that he had undergone intramedullary nailing operation in his left femur due to a pathological fracture approximately 8 years ago in the orthopedics clinic of our institution. The patient underwent 3 consecutive surgeries by our plastic and neurosurgical team. The patient was followed-up in the neuro-intensive care unit between the surgical sessions and 1 week after the last operation. Afterwards, he was transferred to the neurosurgical department. No postoperative complication was detected. The preoperative signs were recovered. During his 6th month follow-up control-visit, all his preoperative symptoms were improved. In addition, the patient was satisfied with his postoperative cosmetic improvement. In conclusion, virtual surgical planning and intraoperative surgical navigation systems can make the challenging cases possible to operate with increasing the safety margin of the surgical procedures for polyostotic FD. Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of Mutaz B. Habal, MD.