Original ArticlesClinical Factors Affecting Survival in Pediatric Vascular Tumors of the Head and NeckCheng, Jeffrey MD*; Jung, Sin-Ho PhD†; Gao, Junheng MS†Author Information *Department of Head and Neck Surgery and Communication Sciences, Duke University Medical Center †Department of Biostatistics and Bioinformatics, Duke University, Durham, NC. Address correspondence and reprint requests to Jeffrey Cheng, MD, Duke University Medical Center, Box 3805, Durham, NC 27710; E-mail: email@example.com Received 10 July, 2019 Accepted 26 August, 2019 The authors report no conflicts of interest. Supplemental digital contents are available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.jcraniofacialsurgery.com). Journal of Craniofacial Surgery: May 2020 - Volume 31 - Issue 3 - p 628-629 doi: 10.1097/SCS.0000000000006040 Buy SDC Metrics Abstract Clinical factors associated with the behavior and outcomes of nonbenign, head, and neck vascular tumors in children are not well described. Our aim is to provide descriptive information and identify prognostic factors associated with lower overall survival for children with these types of tumors. A retrospective cohort study was performed using the SEER database (years 1973–2015). Children aged 18 years and under with the diagnosis of a vascular tumor with locally aggressive or borderline and malignant behavior, classified by ICD-O-3, within the head and neck were included. Vascular tumors with benign behavior as classified by ISSVA were excluded. One hundred forty-eight children were identified. Mean age was 9.9 years (SD = 6.4). A gender predilection was noted with more males affected, female (37.8%) and male (62.2%), P = 0.0031. Majority of the children were white (79.4%) and angiosarcoma was the most common histologic subtype (68.2%). Children had a significantly better overall survival than adults with head and neck vascular tumors, P < 0.0001. Univariate and multivariate analysis did not reveal any factors with significant association to overall survival. Vascular tumors in the head and neck in children most commonly affect males and white children, with angiosarcoma as the most common histologic subtype. Children seem to have a more favorable overall survival compared to adults. © 2020 by Mutaz B. Habal, MD.