Special EditorialsTissue Engineering and Regenerative Medicine in Craniofacial Reconstruction and Facial AestheticsBorrelli, Mimi R. MBBS, MSc; Hu, Michael S. MD, MPH; Longaker, Michael T. MD, MBA; Lorenz, Hermann Peter MD, FACSAuthor Information Department of Surgery, Division of Plastic Surgery, Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA. Address correspondence and reprint requests to Hermann Peter Lorenz, MD, FACS, Professor and Chief, Pediatric and Craniofacial Surgery, Department of Surgery, Division of Plastic and Reconstructive Surgery, Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, 257 Campus Drive, Stanford, CA 94305–5148; E-mail: email@example.com Received 4 April, 2018 Accepted 6 June, 2019 This work was supported by the NIH grant R01 GM116892. The authors report no conflicts of interest. Journal of Craniofacial Surgery: January/February 2020 - Volume 31 - Issue 1 - p 15-27 doi: 10.1097/SCS.0000000000005840 Buy Metrics Abstract The craniofacial region is anatomically complex and is of critical functional and cosmetic importance, making reconstruction challenging. The limitations of current surgical options highlight the importance of developing new strategies to restore the form, function, and esthetics of missing or damaged soft tissue and skeletal tissue in the face and cranium. Regenerative medicine (RM) is an expanding field which combines the principles of tissue engineering (TE) and self-healing in the regeneration of cells, tissues, and organs, to restore their impaired function. RM offers many advantages over current treatments as tissue can be engineered for specific defects, using an unlimited supply of bioengineered resources, and does not require immunosuppression. In the craniofacial region, TE and RM are being increasingly used in preclinical and clinical studies to reconstruct bone, cartilage, soft tissue, nerves, and blood vessels. This review outlines the current progress that has been made toward the engineering of these tissues for craniofacial reconstruction and facial esthetics. © 2020 by Mutaz B. Habal, MD.