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Vitamin E Promotes Bone Formation in a Distraction Osteogenesis Model

Akçay, Hüseyin DDS, PhD*; Kuru, Keremcan DDS, PhD*; Tatar, Birkan DDS*; Şimşek, Fatma MD, PhD

doi: 10.1097/SCS.0000000000005685
Original Articles

The long consolidation period of distraction osteogenesis (DO) may lead to complications such as pain, infection, fracture, scar formation, malunion and delayed union. The aim of this study was to evaluate the effect of systemic Vitamin E application during mandibular DO on new bone regeneration in a rabbit model. 16 adult male 8 months old New Zealand rabbits underwent mandibular lengthening with a distractor for the study. After the latency period of 5 days, the distractor was activated at a rate of 0.5 mm/12 hours for 7 days. Experimental animals received 200 mg/kg injections of α-tocopherol intraperitoneally for 7 days starting with the operation. After the consolidation period of 30 days, rabbits were sacrificed. Lengthened mandibles were obtained and subjected to dual-energy X-ray absorptiometry (DXA), radiologic and histomorphometric analysis. Statistically, bone mineral density and bone mineral content values were found to be significantly higher in the experimental group than the control group during DXA analysis. Rabbits in the experimental group had statistically higher scores in terms of osteoblast, osteoclast, vessel numbers and newly formed bone area than the control group. Results of the present study showed that systemic Vitamin E application during DO may stimulate new bone formation in rabbits and thus results in shortened treatment time.

*Department of Oral and Maxillofacial Surgery, Izmir Katip Celebi University, Faculty of Dentistry

Department of Histology and Embriyology, Ataturk Training and Research Hospital, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey.

Address correspondence and reprint requests to Keremcan Kuru, DDS, PhD, Department of Oral and Maxillofacial Surgery, Izmir Katip Celebi University, Faculty of Dentistry, Aydinlikevler Mah. Cemil Meriç Cad., Izmir Katip Celebi Universitesi Dis Hek. Fak. Agiz, Dis ve Cene Cerrahisi Ad., 35640 Cigli, Izmir, Turkey; E-mail:

Received 23 July, 2018

Accepted 25 April, 2019

The authors report no conflicts of interest.

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© 2019 by Mutaz B. Habal, MD.