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Eyelid Melanoma in the United States

A National Cancer Database Analysis

Oliver, Jeremie D. BS, BA*; Boczar, Daniel MD; Sisti, Andrea MD; Huayllani, Maria T. MD; Restrepo, David J. MD; Spaulding, Aaron C. PhD; Gabriel, Emmanuel MD, PhD§; Bagaria, Sanjay MD§; Rinker, Brian D. MD; Forte, Antonio J. MD, PhD†,‡

doi: 10.1097/SCS.0000000000005673
Clinical Studies

Background: Eyelid melanoma (EM) is a rare condition that accounts for <1% of all cutaneous melanomas. In this analysis, patients diagnosed with EM in the United States were compared to those with other melanomas in the head and neck.

Methods: The National Cancer Database was used to select patients with head and neck melanoma from 2004 to 2015.

Results: A total of 137,233 patients met the criteria of the study. Among them, 2694 were diagnosed with EM (2%) and 134,539 in other head and neck locations (98%). Regarding the patients with EM, the mean age was 68.56 years (standard deviation 14.04). A greater number of them were treated in Academic/Research Programs (53.6%), insured by Medicare (55.7%), tumor in situ (52.2%), stage 0 (49%), and without ulceration (75.9%). The mean time to treatment commencement was 18.96 days for EM compared to 14.4 days for other melanoma in the head and neck regions (P < 0.001). There was a greater proportion of EM in female patients (odds ratio [OR] 2.371 [2.191–2.566], P < 0.001), compared to male; age greater than 80 years (OR 1.622 [1.360–1.934], P < 0.001) compared to 0 to 49 years. Moreover, EM was an independent predictor for treatment in Academic/Research Programs (OR 1.258 [1.160–1.365], P < 0.001) and diagnosis at autopsy (OR 1.414 [1.083–1.847], P = 0.011) compared to other melanoma in the head and neck region.

Conclusion: These novel findings have the potential to guide clinical decision making in head and neck melanoma management.

*Mayo Clinic School of Medicine, Mayo Clinic, Rochester, MN

Division of Plastic Surgery

Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery

§Department of Surgery, Mayo Clinic, Jacksonville, FL.

Address correspondence and reprint requests to Antonio J. Forte, MD, PhD, 4500 San Pablo Road, Jacksonville, FL; E-mail:

Received 22 March, 2019

Accepted 19 April, 2019

This study was supported in part by the Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery.

The authors report no conflicts of interest.

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© 2019 by Mutaz B. Habal, MD.