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Comparison Effects of Platelet-Rich Fibrin on Macrofat and Shuffling Fat Grafting

Zhai, Zhen MD; Yu, Panxi MD; Huang, Minlu MD; Jin, Xiaolei MD; Yang, Xiaonan MD; Qi, Zuoliang MD

doi: 10.1097/SCS.0000000000005745
Original Articles
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Fat acquisition, processing, and grafting techniques are considered to be the main factors affecting the volume retention rate of fat grafting. Shuffling fat (SF) is obtained by refining macrofat (MF), both of which have been applied in autologous fat grafting. However, few studies have focused on comparison effects of platelet-rich fibrin (PRF) on MF and SF grafting. Grafts were prepared by mixing MF and SF with PRF or normal saline at a ratio of 5:1, and grafted into symmetric recipient sites of a mouse's buttock. Grafts were harvested and analyzed at 4, 8, and 12 weeks. Groups containing PRF showed high volume retention rates and microcosmic evaluation scores at each time point compared with the control groups. Although without improved volume retention rate, group of SF containing PRF showed superior microcosmic evaluations compared with group of MF containing PRF. The results demonstrated that both the efficacy of MF and SF grafting can be enhanced by PRF, with even better quality of grafts for the SF grafting.

Department No. 16 of Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Address correspondence and reprint requests to Xiaonan Yang, MD and Zuoliang Qi, MD, Department No. 16 of Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; E-mails: yxnan@aliyun.com; public_qi@163.com

Received 27 April, 2019

Accepted 27 May, 2019

The authors report no conflict of interests.

© 2019 by Mutaz B. Habal, MD.