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Effect of Platelet-Rich Fibrin and Bone Morphogenetic Protein on Dental Implant Stability

Alhussaini, Ali H. Abbas BDS, MSc

doi: 10.1097/SCS.0000000000005131
Clinical Studies

Recombinant human bone morphogenetic protein-2 (rhBMP-2) and platelet-rich fibrin (PRF) bioactive materials have been used to enhance healing and improve dental implant stability. This study aimed to compare the effect of rhBMP-2 and PRF bioactive materials on dental implant stability at different intervals and to evaluate the correlation of implant length and diameter with implant stability.

Two bioactive materials were compared to evaluate their effect on dental implant stability. A total of 32 patients (102 dental implants) were divided into 3 groups: 24 dental implants with bone morphogenetic protein (BMP), 27 dental implants with PRF, and 51 dental implants without BMP or PRF (control group). Data were statistically analyzed to determine the bioactive material with the best effect on implant stability.

Implant stability did not significantly differ between the groups immediately after implant insertion (first reading; P > 0.05). The implant stability of the rhBMP-2 group was significantly better than those of the PRF and control groups 6 weeks after implant insertion (second reading; P = 0.001). After 12 weeks, the effect of rhBMP-2 on implant stability was highly significant and better than that of the other groups (third reading; P < 0.001).

Dental implants coated with BMP have a better effect on stability than those with PRF alone and those without PRF or BMP.

Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Baghdad, Baghdad, Iraq.

Address correspondence and reprint requests to Ali H. Abbas Alhussaini, BDS, MSc, Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Baghdad, Bab-Almoadham, PO Box 14177, Baghdad, Iraq; E-mail:

Received 23 September, 2017

Accepted 2 October, 2018

The author reports no conflicts of interest.

© 2019 by Mutaz B. Habal, MD.