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The Natural Growth Rate of Skull Base Meningiomas Compared With Non-Skull Base Meningiomas

Yao, Xiang, MD*; Wei, Ting, MD; Zhang, Haoran, MD*; Li, Jialin, MD*; Tang, Aiwen, MD*; Ren, Ke, PhD*

Journal of Craniofacial Surgery: June 2019 - Volume 30 - Issue 4 - p 1231–1233
doi: 10.1097/SCS.0000000000005468
Clinical Studies

In the present study, the authors assessed the differences in natural growth rates between skull base and non-skull base meningiomas by meta-analysis. Studies investigating meningioma growth rate were compiled from PubMed, Embase, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature database, and the China National Knowledge Infrastructure databases. A systematic review and meta-analysis of the collected literature were conducted using Stata 12.0 software. A total of 7 observational cohort studies, including 361 patients with untreated meningiomas, were included in the study. Meta-analysis showed that the weighted mean difference for absolute growth rate (years), relative growth rate (years), and doubling time (month) were 0.42 (95% confidence interval [CI]: 0.20–0.64, P <.0001), 1.08 (95%CI: 0.85–1.32, P <.0001), and −0.56 [95%CI: (−0.78)–(−0.33), P <.0001)] respectively. These findings indicate that the natural growth rate of skull base meningioma is less than that of non-skull base meningioma.

*Department of Radiology, The Xiang’An Hospital of Xia Men Uneversity, Xia Men

The Hospital of North Sichuan Medical College, Nan Chong, China.

Address correspondence and reprint requests to Ke Ren, PhD, Xia Men Uneversity, Xia Men. Xiang an nan Rd, Xiangan District, Xia Men 361000, China; E-mail:

Received 7 September, 2017

Accepted 28 January, 2019

The authors report no conflicts of interest.

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© 2019 by Mutaz B. Habal, MD.