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Micro-Autologous Fat Transplantation Combined With Platelet-Rich Plasma for Facial Filling and Regeneration

A Clinical Perspective in the Shadow of Evidence-Based Medicine

Ozer, Kadri, MD*; Colak, Ozlem, MD

Journal of Craniofacial Surgery: May 2019 - Volume 30 - Issue 3 - p 672–677
doi: 10.1097/SCS.0000000000005122
Original Articles

Despite the popularity of lipofilling procedures in recent years, the presence of older habits still in fat graft harvesting and processing seems to be the biggest obstacle to the final better outcome of fat grafting. Our study is aimed to highlight some strategies what should be done in fat grafting in the shadow of evidence-based medicine and patient-reported outcomes which might be of interest to the clinicians. Between 2015 and 2017, 14 patients were included who underwent facial micro-autologous fat transplantation with platelet-rich plasma injection. The outcome was determined by the difference in presurgery and postsurgery FACE-Q modules, which were designed as patient-reported outcome instrument to evaluate the unique outcomes of patients undergoing facial cosmetic procedures. Surveys conducted were modules of satisfaction with facial appearance, satisfaction with cheeks, satisfaction with skin, psychological function, social function, aging appearance appraisal, and satisfaction with the outcome. All patients were followed up minimum 9 months. No major complications were recorded. The patient-reported FACE-Q satisfaction and FACE-Q quality-of-life presurgery and postsurgery results showed statistically significant improvement (<0.001). Overall satisfaction with the outcome was 87.6 ± 16.8 (range 55–100). A combination of platelet-rich plasma and micro-fat grafting with soft harvesting and processing could be seen a good surgical technique to restore volume and enhance skin quality in facial soft tissue augmentation. The authors believe that with minimum detrimental effect on fat grafting while harvesting, processing, and with the addition of platelet-rich plasma while applying may increase the surgeon's and patient's satisfaction with the outcome.

*Aydin State Hospital, Plastic, Reconstructive and Aesthetic Surgery Clinic, Aydin

Istanbul Okmeydani Training and Research Hospital, Plastic, Reconstructive and Aesthetic Surgery Clinic, Istanbul, Turkey.

Address correspondence and reprint requests to Kadri Ozer, MD, Aydin State Hospital, Plastic, Reconstructive and Aesthetic Surgery Clinic, 09100 Aydin, Turkey; E-mail:

Received 2 June, 2018

Accepted 26 September, 2018

The authors report no conflicts of interest.

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© 2019 by Mutaz B. Habal, MD.