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Recurrence of Biphenotypic Sinonasal Sarcoma With Cerebral Hemorrhaging

Fudaba, Hirotaka, MD, PhD*; Momii, Yasutomo, MD, PhD*; Hirano, Takashi, MD, PhD; Yamamoto, Hidetaka, MD, PhD; Fujiki, Minoru, MD, PhD*

doi: 10.1097/SCS.0000000000004720
Brief Clinical Studies

Biphenotypic sinonasal sarcoma (BSNS) is a newly classified tumor that is characterized by neural and myogenic differentiation. The authors herein report a rare patient of the recurrence of BSNS with intracranial hemorrhaging and a review of the literature. A 70-year-old man presented with disturbance of consciousness and vomiting blood. He had undergone resection of a sinonasal tumor 11 years earlier and shown no recurrence at his last follow-up 4 years ago. Computed tomography showed cerebral hemorrhaging around a low-density mass that occupied the left frontal base and left ethmoid sinus. Total resection was performed. A histological examination of tumor specimens obtained from the first and the second resections revealed almost the same characteristic morphological features and the patient was diagnosed with BSNS. The lesion was negative for any fusion genes, as previously reported. The long-term progression of BSNS is not clear. This case appears to be the first reported recurrence of BSNS with cerebral hemorrhaging. Biphenotypic sinonasal sarcoma should be considered to need long-term follow-up.

*Department of Neurosurgery

Department of Otolaryngology, Oita University Faculty of Medicine, Oita

Department of Anatomic Pathology, Kyushu University, Fukuoka, Japan.

Address correspondence and reprint requests to Hirotaka Fudaba, MD, PhD, Department of Neurosurgery, Oita University Faculty of Medicine, Oita 879-5593, Japan; E-mail: fudaba@oita-u.ac.jp

Received 13 April, 2018

Accepted 12 May, 2018

The authors report no conflicts of interest.

© 2019 by Mutaz B. Habal, MD.