Seasonality of congenital birth defect could help to identify environmental risk factors. Data concerning the seasonality of the prevalence of microtia are little. This article aims to determine whether births of microtia follow a certain pattern.
Data were obtained from 2669 patients with microtia who were admitted to Second Ear Reconstruction Center of Plastic Surgery Hospital, Chinese Academy of Medical Science from January 2007 to December 2013. The controls consist of all living births from the Obstetric Department of the Haidian Maternal & Child Health Hospital during the same time. Seasonal variations in months of births were analyzed by using χ2 test.
A total of 2669 patients with microtia and 89,273 healthy living newborns were included in this study. Birth time peak of the patients occurred in autumn, especially in November, compared with the nadir in the spring, especially in April (P G 0.05). The birth time peak of male patients occurred in autumn, too, especially in October and November, While the valley occurred in spring (April, too). However, the seasonality in female patients is not so apparent with the peak occurred in the tail of summer and autumn, especially in August, November, and September orderly, while the valley occurred in March.
There is a possible seasonality in birth months and a difference between sexes of patients with microtia in this native Chinese population. This approach could be useful to study the etiology of microtia.
*Department of Ear Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences
†Obstetric Department of Haidian Maternal and Child Health Hospital
‡Research Center of Plastic Surgery Hospital, Chinese Academy of Medical Sciences
§Beijing Institute of Genomics, Chinese Academy of Sciences and Key Laboratory of Genome Science and Information, Chinese Academy of Sciences, Beijing, China.
Address correspondence and reprint requests to Dr Qing-Guo Zhang, MD, Second Department of Ear Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, No. 33 Ba-Da-Chu Road, Shi Jing Shan District, 100144 Beijing, China; E-mail: firstname.lastname@example.org
Received 20 January, 2018
Accepted 31 May, 2018
J-TH and QC contributed equally to this article.
This study was supported by grants from the Special Fund for Scientific Research in the Public Interest (201502016 to Y-LC) and National Natural Science Foundation of China (81571924 to Q-GZ and 81671933 to J-TH).
The authors report no conflicts of interest.